Multiple Israeli air defense systems intercepted a ballistic missile launched from Yemen towards central Israel early on August 22, 2025, with the missile reportedly fragmenting mid-air. The incident occurred amidst stalled diplomatic efforts, as Iranian Foreign Minister Mohammad Javad Zarif's call with E3 foreign ministers did not yield progress on the nuclear program. The Israeli military confirmed that several interceptors were launched at the incoming missile, stating the results of the interception were under review, and reported no direct impact or injuries. Hebrew media indicated the missile disintegrated into several projectiles, and despite interception difficulties, the event concluded without damage. Police were on-site to manage debris in the Tel Aviv area, advising the public to stay clear of affected locations. In parallel, diplomatic discussions regarding Iran's nuclear program saw no breakthroughs. A source with knowledge of the E3 foreign ministers' call with Zarif reported that the Iranian minister presented no new proposals. The call began with a confrontational tone, with Zarif questioning the E3's right to trigger a snapback mechanism. While Zarif expressed some openness to an extension of the snapback, he stressed that such a decision rests with the UN Security Council. Zarif also indicated that Iran's enriched uranium stockpile is "buried under the rubble" with no immediate means of removal. He did not express interest in resuming talks with the United States, claiming it is the U.S. that is not interested in negotiations. Furthermore, Zarif asserted Iran's cooperation with the IAEA, without hinting at granting access to UN inspectors. In separate developments, the IDF reportedly attacked a Hezbollah warehouse in Dir Kifa, southern Lebanon, using two missiles launched from the Hula Valley. Lebanese sources confirmed the strike, noting it was carried out via land-to-land missiles. Separately, security sources indicated that Israel is preparing for a "strong" attack on Houthi sites in Yemen. American delegates Tom Barak and Morgan Ortagus are scheduled to return to Beirut next week. Political sources have denied reports that Lebanon has accepted an Israeli response that includes control over some border villages, though other reports suggest Israel has agreed in principle to a gradual endowment of raids and withdrawal in exchange for an industrial area free from population along the border strip.