The U.S. conducted large-scale strikes against multiple Islamic State targets across Syria on Saturday, January 10, 2026, U.S. Central Command announced over the past hour ending at 3:15 a.m. UTC on Jan. 11, according to a report by CBS Evening News on X. This follows a U.S.-led International Coalition confirmation earlier on Jan. 11 of airstrikes targeting an ISIS refuge site near Tulul al-Safa in the Syrian desert, 80 km from Suwayda, as part of operations against sleeper cells, according to Suwayda24 citing the Coalition's Arabic account @CoalitionAR. The strikes occur amid ongoing U.S. efforts to combat ISIS remnants in Syria.